Innovation Platform

SEDDS Technology

Self Emulsified Drug Delivery System — a proprietary platform engineered to dramatically improve the absorption and bioavailability of nutrition and pharmaceutical compounds.

Clinical Evidence

Clinical Trial Results

In a recent double-blind clinical study, SEDDS Coenzyme Q10 softgel has shown almost three times higher bio-availability than traditional Coenzyme product.

287%

Higher bioavailability vs. traditional Coenzyme Q10 products

Clinical Trial Results — CoQ10 Bioavailability Study

About the Lab

SEDDS Technology Research Lab

SEDDS (Self Emulsified Drug Delivery System) Technology Research Lab is the subsidiary research company of MTC Industries which was founded by Dr. Jimmy Wang, in 2001 on Long Island, New York. MTC owns the namesake brand "SEDDS".

The research fellows of SEDDS Technology Research Lab are a group of experienced scientists from top pharmaceutical companies and universities in the United States. Our goal is to develop new formulations and new products to improve and increase the absorption and bio-availability of nutrition and screen new active compounds from wild natural source.

SEDDS Technology Research Lab
Research Focus — Soluble Platform Construction

Research Focus

Soluble Platform Construction

Soluble platform construction of insoluble and active pharmaceutical & Nutraceutical molecules and industrialization. Our research focuses on transforming compounds with excellent efficacy but poor solubility into commercially viable, bioavailable formulations that can reach patients effectively.

Project Background

Beyond the Lipinski Principles

In ten years, in the lead compound library, high solubility and high permeability, high solubility and low permeability, low solubility and high permeability compounds have been a hot research object. To improve the bioavailability of new drugs, the Lipinski Screen Five Principles are summarized based on the experience:

  • Molecular weight of less than 500 Dalton
  • Hydrogen bond acceptor number, no more than 10
  • Number of hydrogen bond donors of not more than 5
  • Lipid water partition coefficient (logP) between -2 to 5

In the process of screening lead compounds, for the considerations of compounds bioavailability, most active compound molecules are abandoned after first round screening. Now the compound library resources (Lipinski drug screening five principles) is fully developed — the compound which has good efficacy, but bad bioavailability has become the gold mining to be developed for new drugs.

Lipinski Drug Screening Principles

Technology Platform

SEDDS Development Framework

Considering the factors of SEDDS technology, our platform covers classification, system design, preparation, detection, and advanced solid-SEDDS development.

Factors

Considering the Factors of SEDDS Technology

  1. 1.The classification of drug vehicles or nutrient molecules
  2. 2.The SEDDS system classification, Surfactant, Cosurfactant, Solvent, Oil selection
  3. 3.The preparation process of SEDDS

Preparation

The Preparation Process of SEDDS

  1. 1.The method of self assembly of the solvent evaporation
  2. 2.Dialysis
  3. 3.The evaporation method of emulsion and solvent
  4. 4.The chemical combination method

Detection

Detection Technology of SEDDS

  1. 1.Its distribution of the morphology, particle size
  2. 2.The measure of entrapment efficiency and drug loading
  3. 3.The extent of oxidized phospholipids
  4. 4.The provisions complying with the general principles of pharmaceutics
  5. 5.The stability of solution (pH, Temperature, Centrifugation, Test)
  6. 6.Zeta potential, Viscosity, Cloud Point, Dye Solubilization Test

Solid-SEDDS

New Technology of s-SEDDS and Its Problems

SEDDS has low stability, the irreversible separation of drug loading and lipid carrier system, big dose, difficultly portable dosage form. Therefore the solid-SEDDS is the developing hotspot at present. Examples of such problems include:

  1. 1.Amount of solidifying excipients may affect the release of the drug.
  2. 2.Nature of the excipients used may affect the drug absorption.
  3. 3.Probability of irreversible phase separation on reconstitution.
  4. 4.Clogging of spray nozzles due to oil content in spray drying method.
  5. 5.Degradation of drug during solidification process.
  6. 6.Reduction in drug loading capacity.
  7. 7.Difficulty in ensuring content uniformity.
  8. 8.Probability of residual solvents used during granulation.

Market Context

Present Market on Research Topic

By the polymeric micelles technology of the solid dispersion, and by the SEDDS technology of the solid dispersion, a series of compounds with good efficacy and insolubility were successfully developed into listed drugs.

Market Research Drug Table
Market Research Chart 1
Market Research Chart 2

Quality Driven by Science

Our Product Line

Each product in the SEDDS portfolio leverages our proprietary drug delivery platform to maximize the bioavailability and efficacy of key nutritional and pharmaceutical compounds.

Cardiovascular Health

SEDDS CoQPure

Ingredients

Coenzyme-Q10

Functions

  • Helps cells produce more energy
  • Supports heart health
  • Acts as an antioxidant helping protect from free radicals
  • Helps reduce the signs of normal aging
  • Helps maintain normal blood pressure levels
  • Helps boost the immune system
  • Supports the nervous system

Applicable Population

Adults

Cardiovascular Health

SEDDS KrilPure

Ingredients

Krill Oil

Functions

  • Supports overall health with Omega-3 fatty acids, DHA, EPA and powerful antioxidants
  • Provides multi-system health benefits with much higher absorption than fish oil and without the aftertaste, side effects, or pollutants from fish sources
  • May be beneficial in the management of heart disease, high cholesterol, high blood pressure, osteoarthritis, depression, and premenstrual syndrome (PMS)

Applicable Population

Adults

Bone & Joint Health

SEDDS Super Joint

Ingredients

Glucosamine, Soybean isoflavone, Epimedium, Collagen, Chondroitin sulfate

Functions

  • Protects articular cartilage, synovial fluid, joints, soft tissue, and the bone joint connection
  • Provides a full range of nutrition to effectively remove harmful enzyme joint cavity, inhibit inflammation, and combine with proteins to form proteoglycans
  • Stimulate the synthesis of new cartilage

Applicable Population

Patients with periarthritis of shoulder, Meniscus injuries, Patella Osteomalacia, Ankylosing spondylitis, External humeral epicondylitis (tennis elbow), Lumbar disc herniation, Osteoporosis, and Rheumatoid arthritis

Brain Health

Super Brain

Ingredients

Galantamine, Calcium ion, Zinc ion, Ginkgo flavone glycoside, ADS PS phosphatidyl serine, Huperzine

Functions

  • Repair the cranial nerve — Galantamine
  • Stabilize brain function — Calcium ion
  • Stabilize Zinc ion — Brain function
  • Dredge the Cerebral blood vessel — Ginkgo flavone glycoside
  • Activate Brain cells — ADS PS
  • Protect the Cerebral nerve — Huperzine

Applicable Population

Those with Alzheimer's disease, Parkinson syndrome, Cerebral infarction, or Chronic brain fatigue

Eye Health

Eye Bright

Ingredients

Haematococcus extract, Safflower seed oil, Chrysanthemum extract, Blueberry extract

Functions

  • Protect eyesight, prevent blindness, glaucoma, cataract, retinal hemorrhage; improvement of myopia, macular degeneration, diabetic retinopathy — Blueberry
  • Prevent aging macular degeneration, protect the retina from oxidative damage in the absorption of light — Chrysanthemum extract
  • Supplement Linoleic acid (~80%); 50% of structural components of retinal neural cells is α-linolenic acid — Safflower seed oil
  • Act as the strongest natural anti-oxidant, cross the blood retinal barrier, repair oxidative damage of any part of the eye — Haematococcus pluvialis

Applicable Population

A variety of eye discomfort health

Skin, Nail & Hair Health

Biotin

Ingredients

Biotin, Folic acid

Functions

  • Provide the precursor of the synthesis of vitamin C
  • Supplement the essential substances for normal metabolism of lipids and protein, help to promote body fat burning, maintain the normal female figure
  • Promote the hair growth, help the lipid metabolism, enhance the immunity, protect the eyesight

Applicable Population

Adult female

Liver & Kidney Health

Super Liver

Ingredients

Thistle

Functions

  • Improve the acute or chronic hepatitis, liver cirrhosis, fatty liver, metabolism of toxic liver injury, cholelithiasis, cholangitis and biliary duct inflammation
  • Improve the symptoms in patients with liver and some biochemical indices such as serum bilirubin, prothrombin, alanine transaminase

Applicable Population

Alcoholic hepatitis, viral hepatitis, toxic mushrooms, cancer

Antioxidant

AstaPure

Ingredients

Haematococcus pluvialis (Astaxanthin), Gelatin, Glycerin

Functions

  • Act as the Antioxidant
  • Scavenge the free radicals, prevent the tumor, improve the eye discomfort and immunity

Applicable Population

Adults

Antioxidant

Resveratrol

Ingredients

SEDDS Resveratrol 100mg

Functions

  • Strong antioxidant properties
  • Promote healthy cholesterol levels
  • Support heart health

Applicable Population

Adults